Alcohol-inducing flushing and esophageal cancer There keeps growing evidence, say researchers in this week’s PLoS Medicine, that people who experience facial flushing after drinking alcohol are at much higher risk of esophageal cancers from alcohol consumption than those who do not. About a third of East Asians display a characteristic physiological response to alcohol consumption which includes facial flushing, nausea, and an increased heart rate click here . This so-called ‘alcoholic beverages flushing response’ is usually predominantly due to an inherited deficiency within an enzyme known as aldehyde dehydrogenase 2 . Although clinicians and the East Asian public know about the alcoholic beverages flushing response generally, few are aware of the accumulating evidence that ALDH2-deficient individuals are at much higher threat of esophageal cancer from alcohol consumption than individuals with fully active ALDH2.
In the current dose-finding part of the AF-002JG study, 47 patients with ALK-rearranged NSCLC began oral alectinib a time a median of 18 days after discontinuing crizotinib twice. The dose varied from 300 to 900 mg. Dose-limiting unwanted effects of grade 3 headache and grade 3 neutropenia were reported by one individual each given a twice-daily dose of 900 mg, and 26 percent of the patients needed dose decrease or interrupted treatment because of side effects, the researchers say. Nevertheless, grade three or four 4 adverse events were rare, most commonly elevated gamma-glutamyl transpeptidase , neutrophil decrease and hypophosphatemia . Four other serious grade 4 events were reported in three sufferers but judged as unrelated to alectinib .