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The RNA is translated right into a protein subsequently. ‘Our study has a broad influence for understanding transcriptional regulation of gene expression and also the pathogenesis of neurodegeneration due to extended polyglutamine proteins,’ says Xiao-Jiang Li, MD, PhD, Distinguished Professor of Human Genetics in Emory University School of Medicine and the paper’s senior author.. Abnormal glutamine repeats hinder key transcription factor, leading to neurodegeneration Although repeating sequences of three nucleotides encoding some of the bodies’ 20 amino acids are a normal part of protein composition, abnormal expansion of trinucleotide repeats is the known cause of multiple inherited neurodegenerative disorders, including Huntington disease.