Histopathological Findings and Gross Mucosal Appearance All 11 individuals with the cord colitis syndrome underwent diagnostic colonoscopy with biopsy during presentation. On inspection, 9 patients experienced mucosal erythema, 5 had edematous mucosa, and 4 had mucosal ulcerations. Only 1 1 individual had hemorrhagic mucosa; no patients had pseudomembranes. Thirty-seven biopsy specimens from the 11 patients were reviewed. The degree of inflammatory activity ranged from none to serious. Basal plasmacytosis had not been a prominent feature, identified in only 1 biopsy specimen from 1 patient.In the remaining 90 percent of instances are believed to have an elevated risk of developing cancer in relation to genetic variants much less powerful but more regularly, for example, doubles the risk of experiencing a tumor that lacks this little change, called polymorphism. Within the last decade, hundreds of studies have been conducted searching for polymorphisms connected with a larger propensity to suffer probably the most frequent individual tumors. These testing, called GWAS, have found a universal problem: many times the small genetic change observed seems to have no activity or function to explain because it is connected with more cancers.