Rates of recurrent venous bleeding and thromboembolism were comparable in the two study groups no matter age, sex, absence or existence of obesity, level of renal function, or degree of pulmonary embolism. We decided to start therapy with a rigorous rivaroxaban program for the first 3 weeks for two reasons. In previous studies, failure to supply adequate initial therapy resulted in unacceptable recurrence rates.4,9,18,19 Furthermore, in phase 2 studies, the use of twice-daily rivaroxaban led to an earlier steady state, higher trough levels, and better thrombus regression at 3 weeks than did administration once-daily. One concern about the intensified preliminary dosage of rivaroxaban was that it could potentially increase the risk of hemorrhage.Alcoholism 15. Tobacco intake 16. Consumption of caffeine. HOME CURES for Acne 1. You can pound orange peel with water and apply the paste on pimples break-outs to eliminate acne. 2. Program of lemon juice is an effective do-it-yourself solution for acne. 3. Intake of 2-3 seeds of raw garlic daily purifies bloodstream and prevents acne. Rubbing natural garlic on acne heals them up. 4. You can apply a paste crafted from coriander leaf juice or any other mint leaf juice and a pinch of turmeric powder on acne.