Previous studies wanting to identify a effective and safe option to warfarin for individuals with atrial fibrillation have most had specific limitations. The mix of aspirin and clopidogrel was far better than aspirin alone13 but less effective than warfarin.14 Subcutaneous idraparinux was more effective than warfarin but was connected with a substantially higher threat of bleeding.15 Ximelagatran, an earlier direct thrombin inhibitor, appeared to be similar to warfarin with respect to efficacy and safety but was found to be hepatotoxic.16 In our serial measurement of liver function, we did not find evidence of hepatotoxicity with dabigatran.Results demonstrated significant improvements in the QOL areas of mental health, public functioning, general health, and physical functioning. Outcomes will be published in the February 2009 problem of Alcoholism: Clinical & Experimental Study and are currently available at Early Look at. Alcoholic beverages dependence is a persistent and disabling disorder, said Helen M. Pettinati, professor of psychology in the division of psychiatry, and director of the division of treatment analysis at the University of Pennsylvania College of Medicine. Heavy drinking is associated with broad impairments in health-related QOL, with the largest impact typically discovered for mental health and social functioning.