The abstract was chosen by participants in the meeting as one of the 11 high-effect abstracts out of hundreds presented on this issue. Subsequently to the recognition, the business continued its efforts on the Erk inhibitor system, including identification of an optimized molecule. Related StoriesNew results reveal association between colorectal cancer and melanoma medication treatmentCrucial change in one DNA base predisposes children to aggressive type of cancerNew RNA test of blood platelets can be used to detect area of cancerAn optimized Erk inhibitor compound, AEZS-140, and back-up candidates were defined as a total consequence of the development initiatives. AEZS-140 and the back-up candidates demonstrate improved plasma exposure in rodents and also enhanced anti-tumor efficacy in comparison to the previous lead compound, AEZS-134.ODS may be the Delta Dental plan in Oregon and has a bit more than half of the dental care insurance market in Oregon far before its competitors. Positive rating movement could take place if ODS proceeds to experience favorable trends in earnings and capitalization, reports significant premium growth while enhancing its level of risk-modified capital or if its business becomes more diversified through product, marketplace segment or geographic expansion. Key rating factors that could result in negative rating actions add a significant decline in membership, premium revenue, reporting of large operating losses or the business experiences a drastic decline in its risk-adjusted capital.